| This program aims to teach the pathophysiology and pharmacology
of inflammation to undergraduate students of pharmacology, medicine,
dentistry and biological sciences. On completion of this package the
student should be able to:
-describe the timescale and the cardinal signs of inflammatory
response to tissue injury
- list the varous chemical mediators involved, describe and explain
their local and systemic effects
- explain the molecular mechanisms of cell accumulation and activatiom
- describe the major processes involved in tissue repair
- describe and explain the pharmacological actions of the major
classes of anti-inflammatory drugs
The program covers the main elements, major cardinal signs and
timescale of the processes involved in the inflammatory response;
the microcirculation; inflammatory mediators - the synthesis, site
and mechanism of histamine, bradykinin, nitric oxide, eicosanoids,
neuropeptides and cytokines; cell accumulation - molecular mechanisms
involved in neutrophil accumualtion at the site of injury, adherance,
marginisation and extravasation; mechanisms of tissue repair and
healing; the pharmacology (names, structure, mechanisms of action
and toxicity) of steroidal and non-steroidal anti-inflammatory drugs
and the disease modifying anti-arthritic drugs.
The program may be used for independent study (primary teaching
or revision) and would occupy students for 4-5 hours of intensive
study. The interactive quizz sections may also be useful for self
assessment. The program contains a HELP facility and a bibliography.
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