| The program shows a G-protein coupled receptor embedded in the
cell membrane and allows exploration of the molecular structures
involved.
The example used is the 2 adrenoceptor found in airways smooth
muscle.
A diagramatic representation of the effects of stimulating this
receptor is presented.
The nature of the natural ligand (adrenaline) for the receptor
and its source is presented and the binding sites of the adrenaline
to the amino acids of the receptor.
A representation of the process of signal transduction across
the cell membrane and the role of the G-protein in the production
of the second messenger c-AMP is explainedc together with the concept
of signal amplification.
The speed of response is compared with that of other types of
receptor mechanisim.
The effects of analogues of the natural ligand (salbutamol and
propranolol) are explained and the use of salbutamol is illustrated.
A summary screen highlights the main points in the program and allows
users to jump directly to any appropriate part of the program.
|