| The aims of this courseware is to give the student an understanding
of the basic principles of drug metabolism including routes of metabolism.
The learning objectives are best defined by the course tutor but,
after using the program, the student should know;
- where drug
metabolism occurs
- why drug metabolism is important
- some of the major routes of metabolism including the principles
of phase 1 and phase 2 metabolism
The program covers the basic principles of drug metabolism (where,
why, how?) including the concept of phase 1 and 2 metabolism. Routes
of metabolism are illustrated by animated examples and further information
can be obtained about the enzyme and cofactor(s) involved as well
as the actual reaction mechanism. For cytochrome P450, the catalytic
cycle is also given as is he further metabolism of gluctathione
conjugates.
There are short quizzes after each section and a longer intergrative
quizz (based on the metabolism of aspirin) at the end. Students
can skip over these quizzes if required. There is a map function
to help the student find their place and a drug glossary defining
the drugs (and some other terms) used.
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