(University of Strathclyde)

Available in Windows and Web/Intranet Versions ISBN: 1 84211 032 2
Programmed by : Frances Penny
Subject Specialist : Dr D.G.Watson

This package focuses on calculation of the content of active ingredients in formulations using chromatographic data

[Screenshot]
A screen from one of the modules
Contents

  1. Determinations by HPLC Using Internal Standards
    • Introduction to Method: Determination of Dexamethasone in Tablets
    • Example 2: Determination of Betamethasone in Tablets
    • Example 3: Determination of Prednisone in Tablets
    • Example 4: Determination of Betamethasone Valerate in Cream
    • Example 5: Determination of Triamcinoline in Tablets
  2. Determinations by HPLC Using External Standards
    • Introduction to Method: Determination of Paracetamol in Oral Solution
    • Example 2: Determination of Cefuroxime in Injection
    • Example 3: Determination of Sodium Fusidate in Ointment
  3. Determinations by GC Using Internal Standards
    • Introduction to Method: Determination of Miconazole in a Cream
    • Example 2: Determination of Hyoscine Hydrobromide in Tablets
    • Example 3: Determination of Chlorpheniramine Maleate in Oral Solution

The package allows the user to:

  1. Develop the ability to interpret British/European Pharmacopoeial Assays
  2. Accurately interpret chromatographic data and sample manipulations in order to calculate drug content in formulations.

On completion of this package, the student will be able to:-

  1. Carry out calculations from chromatographic data by the internal standard method.
  2. Carry out calculations from chromatographic data by the external standard method.

Hardware and Software Requirements

Windows Version
 The package is supplied on a CD-ROM Installation Disc and can be installed to a local hard disc or network drive. The minimum requirement is a PC with 100MHz Pentium processor , 8Mb of RAM and a VGA monitor capable of displaying 16-bit color (65, 536 colors) at 640 x 480 resolution. The program is 32-bit and is compatible with Windows 95, 98 and NT.
Web Version
The package is supplied on a CD-ROM Installation Disc for installation to a web server. The software runs on PC clients only. The minimum requirement is a 200MHz Pentium processor with 32Mb of RAM and a Super VGA monitor capable of displaying 16-bit color (65,536 colors) at 800 x 600 resolution. The program is compatible with both Netscape Navigator 4.x and Internet Explorer 4 or better and requires Java and Javascript to be enabled on browsers.