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| Available in Windows and Web/Intranet Versions | ISBN: 0 9532751 7 5 |
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Subject Specialist: Professor Gordon Armidon, University of Michigan. This package is designed to introduce the student to biopharmaceutics. The student first studies the basics of biopharmaceutics then continues by looking at the application of biopharmaceutics to oral drug delivery. The student finishes by looking at the regulatory standards for oral drug delivery.
The package is divided into 3 subjects containing a total of 7 activity modules, as illustrated below. The diagram above is a single screen from one of the activity modules.
Contents of Package
Details of three of the activities are given below as examples to show the level and depth of information contained within the package. Basics of Biopharmaceutics is split into three sections: i) Biopharmaceutics and Pharmacokinetics (Biopharmaceutics - definition and relating terms; Bioavailability - definition, Cpvs t: AUC, Tmax, Cmax; Pharmacokinetics - definition, absorption, disposition, elimination, kinetic analysis - models, parameters - t1/2, K, (abs)t1/2, ka, Vd; Bioequivalence - definition, therapeutic equivalence evaluation codes). ii) Transport (Paracellular Transport; Passive Transport - Fick’s First Law; Endocytosis Transport; Carrier Mediated Transport - active transport (primary and secondary, carrier-mediated transport); A Theory of Mass Transport). iii) Different Routes of Drug Administration (Routes of Administration - buccal or sublingual, eye, IA, IM, inhalation, IP, IV, nasal, rectal, SC, spinal, topical and vaginal). Gastrointestinal Tract Factors (from the subject Oral Drug Delivery) covers four main areas: I) Anatomy and Morphology (Overview; Stomach; Small Intestine; Large Intestine). ii) Secretion (Salivary Secretion; Gastric Secretion; Pancreatic Secretion; Biliary Secretion; Intestinal Secretion). iii) Motility (Overview; Stomach - gastric emptying, fed vs fasted state; Small Intestine - transit time, fed vs fasted state; Large Intestine - transit time, fed vs fasted state). v) Nutrient Absorption Effect (Fat; Carbohydrate; Protein). Controlled Released Dosage Forms (from the subject Oral Drug Delivery) covers six main areas: i) Introduction. ii) Terminology (Sustained Release; Controlled Release; Zero-Order Release; First-Order Release). iii) Factors Influencing CR (Biological Factors - elimination rate, half-life, absorption, metabolism, duration of action; Physicochemical Factors - dose size, ionization, pKa, aqueous solubility, partition coef ficient, stability). iv) Types of Oral CR (Diffusional Systems - reservoir devices, matrix devices; Dissolution Controlled Systems; Diffusion and Dissolution Controlled Systems; Osmotically Controlled Systems; Ion-Exchange Systems). v) Simulation (Defining Models; Nifedipine; Zero-Order Release Simulations; First-Order Release Simulations). vi) Regulation (Potential Bioavailability Problems - food administration, First Pass Metabolism, Dose Dumping; Demonstration of Safety and Efficacy; Dissolution Test).
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